Little is known about the roles of integral membrane proteins beyond channels, carriers or receptors in meiotic oocytes. The transmembrane protein Fam70A was previously identified as a likely “female fertility factor” in Fox3a-knockout mouse ovaries where almost all follicles underwent synchronous activation and the mice became infertile very early.

However, whether Fam70A functions in oocyte meiosis remains unknown. Therefore, the present study aimed to address this question.Co-immunoprecipitation, immunogold labelling-electronmicroscopy, co-localization and yeast two-hybrid assays were used to verify the interaction. Antibody or small interfering RNA transfection was used to deplete the proteins.

Immunofluorescence, immunohistochemistry and live tracker staining were used to examine the localization or characterize phenotypes. Western blot was used to examine the protein level. Fam70A was enriched in oocyte membranes important for normal meiosis. Fam70A depletion remarkably disrupted spindle assembly, chromosome congression and first polar body extrusion, which subsequently increased aneuploidy and abnormal fertilization.

Moreover, Fam70A directly bound Wnt5a, the most abundant Wnt member within oocytes. Depletion of either Fam70A or Wnt5a remarkably increased adenomatous polyposis coli (APC), which stabilizes active β-catenin and microtubules. Consequently, depletion of either Fam70A or Wnt5a remarkably increased p-β-catenin (inactive form) and acetylated tubulin, while APC knockdown remarkably decreased these two. Furthermore,

Mouse Gelsolin (GS) ELISA Kit
RD-GS-Mu-96Tests	Reddot Biotech	96 Tests	EUR 677

Human Gelsolin (GS) ELISA Kit
DLR-GS-Hu-48T	DL Develop	48T	EUR 441
Description: A sandwich quantitative ELISA assay kit for detection of Human Gelsolin (GS) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Gelsolin (GS) ELISA Kit
DLR-GS-Hu-96T	DL Develop	96T	EUR 570
Description: A sandwich quantitative ELISA assay kit for detection of Human Gelsolin (GS) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Gelsolin (GS) ELISA Kit
DLR-GS-Mu-48T	DL Develop	48T	EUR 489
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Gelsolin (GS) in samples from serum, plasma or other biological fluids.

Mouse Gelsolin (GS) ELISA Kit
DLR-GS-Mu-96T	DL Develop	96T	EUR 635
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Gelsolin (GS) in samples from serum, plasma or other biological fluids.

Human Gelsolin (GS) ELISA Kit
RDR-GS-Hu-48Tests	Reddot Biotech	48 Tests	EUR 455

Human Gelsolin (GS) ELISA Kit
RDR-GS-Hu-96Tests	Reddot Biotech	96 Tests	EUR 629

Mouse Gelsolin (GS) ELISA Kit
RDR-GS-Mu-48Tests	Reddot Biotech	48 Tests	EUR 511

Mouse Gelsolin (GS) ELISA Kit
RDR-GS-Mu-96Tests	Reddot Biotech	96 Tests	EUR 709

GS-6207
HY-111964	MedChemExpress	100mg	EUR 7970

GS-444217
HY-100844	MedChemExpress	10mM/1mL	EUR 486

GS 39783
B6918-10	ApexBio	10 mg	EUR 308

GS 39783
B6918-50	ApexBio	50 mg	EUR 1136

GS-9973
B3553-10	ApexBio	10 mg	EUR 168
Description: GS-9973 is a selective inhibitor of Syk with IC50 value of 7.7 nM [1]. Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase that is expressed mainly in hematopoietic cells and acts as a mediator of immunoreceptor signaling.

GS-9973
B3553-25	ApexBio	25 mg	EUR 241
Description: GS-9973 is a selective inhibitor of Syk with IC50 value of 7.7 nM [1]. Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase that is expressed mainly in hematopoietic cells and acts as a mediator of immunoreceptor signaling.

GS-9973
B3553-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 224
Description: GS-9973 is a selective inhibitor of Syk with IC50 value of 7.7 nM [1]. Spleen tyrosine kinase (Syk) is a cytoplasmic tyrosine kinase that is expressed mainly in hematopoietic cells and acts as a mediator of immunoreceptor signaling.

GS-9620
A3444-10	ApexBio	10 mg	EUR 258
Description: GS-9620 is an orally active TLR7 agonist with EC50 of 291 nM. [1]Toll-like receptor 7 (TLR7) is a pathogen recognition receptor which plays an important role in the detection of, and the innate immune response to, pathogens.

GS-9620
A3444-5	ApexBio	5 mg	EUR 174
Description: GS-9620 is an orally active TLR7 agonist with EC50 of 291 nM. [1]Toll-like receptor 7 (TLR7) is a pathogen recognition receptor which plays an important role in the detection of, and the innate immune response to, pathogens.

GS-9620
A3444-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 189
Description: GS-9620 is an orally active TLR7 agonist with EC50 of 291 nM. [1]Toll-like receptor 7 (TLR7) is a pathogen recognition receptor which plays an important role in the detection of, and the innate immune response to, pathogens.

GS-9620
A3444-50	ApexBio	50 mg	EUR 862
Description: GS-9620 is an orally active TLR7 agonist with EC50 of 291 nM. [1]Toll-like receptor 7 (TLR7) is a pathogen recognition receptor which plays an important role in the detection of, and the innate immune response to, pathogens.

GS-7340
B8021-10	ApexBio	10 mg	EUR 177
Description: GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340
B8021-100	ApexBio	100 mg	EUR 595
Description: GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340
B8021-5	ApexBio	5 mg	EUR 131
Description: GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340
B8021-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 171
Description: GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-7340
B8021-50	ApexBio	50 mg	EUR 444
Description: GS-7340(Tenofovir alafenamide) is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.

GS-9973
2669-1	Biovision		EUR 142

GS-9973
2669-5	Biovision		EUR 414

50ml Skirted Centrifuge Tube, Green Cap, 25/Bag
TK943-G	Bio Basic	1PK, 25UNIT	EUR 56.09

50ml Skirted Centrifuge Tube, Yellow Cap, 25/Bag
TK943-Y	Bio Basic	1PK, 25UNIT	EUR 56.09

50ml Skirted Centrifuge Tube, Yellow Cap, Sterile, 25/Bag
TK943-YS	Bio Basic	1PK, 25UNIT	EUR 58.1

Recombinant Gelsolin (GS)
4-RPA372Bo01	Cloud-Clone	EUR 521.12 EUR 242.00 EUR 1679.20 EUR 626.40 EUR 1152.80 EUR 412.00 EUR 4048.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Bovine Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Hu01	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Hu02	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Hu03	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Hu04	Cloud-Clone	EUR 485.28 EUR 233.00 EUR 1544.80 EUR 581.60 EUR 1063.20 EUR 388.00 EUR 3712.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Mu01	Cloud-Clone	EUR 503.20 EUR 238.00 EUR 1612.00 EUR 604.00 EUR 1108.00 EUR 400.00 EUR 3880.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Gelsolin expressed in: E.coli

Recombinant Gelsolin (GS)
4-RPA372Ra01	Cloud-Clone	EUR 458.40 EUR 226.00 EUR 1444.00 EUR 548.00 EUR 996.00 EUR 370.00 EUR 3460.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Gelsolin expressed in: E.coli

Cellufine MAX GS
21-300	JNC America	100 ml	EUR 505

Cellufine MAX GS
21-303	JNC America	10 lt	Ask for price

alfa-Conotoxin GS
5-00391	CHI Scientific	4 x 1mg	Ask for price

Gelsolin (GS) Antibody
20-abx128513	Abbexa	EUR 356.00 EUR 133.00 EUR 996.00 EUR 495.00 EUR 300.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx129516	Abbexa	EUR 411.00 EUR 133.00 EUR 1135.00 EUR 551.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx131113	Abbexa	EUR 356.00 EUR 133.00 EUR 996.00 EUR 495.00 EUR 300.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx100097	Abbexa	EUR 356.00 EUR 133.00 EUR 996.00 EUR 495.00 EUR 300.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx100098	Abbexa	EUR 356.00 EUR 133.00 EUR 996.00 EUR 495.00 EUR 300.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx100099	Abbexa	EUR 425.00 EUR 133.00 EUR 1177.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx100100	Abbexa	EUR 453.00 EUR 133.00 EUR 1288.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx132379	Abbexa	EUR 300.00 EUR 718.00 EUR 384.00 EUR 154.00 EUR 244.00	100 ug 1 mg 200 ug 20 ug 50 ug

Gelsolin (GS) Antibody
20-abx176577	Abbexa	EUR 398.00 EUR 133.00 EUR 1080.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody
20-abx176578	Abbexa	EUR 1135.00 EUR 551.00	1 mg 200 ug

Gelsolin (GS) Antibody
20-abx176579	Abbexa	EUR 1372.00 EUR 648.00	1 mg 200 ug

Guanosine (GS) Antibody
20-abx178984	Abbexa	EUR 439.00 EUR 133.00 EUR 1274.00 EUR 606.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Recombinant Human GS
P0309	FN Test	100ug	EUR 522.36
Description: Recombinant Human protein for GS

Acalisib (GS-9820)
B5831-10	ApexBio	10 mg	EUR 224
Description: Acalisib (GS-9820) is a potent and selective inhibitor of PI3K? with IC50 value of 12.7 nM [1].

Acalisib (GS-9820)
B5831-100	ApexBio	100 mg	EUR 734
Description: Acalisib (GS-9820) is a potent and selective inhibitor of PI3K? with IC50 value of 12.7 nM [1].

Acalisib (GS-9820)
B5831-5	ApexBio	5 mg	EUR 154
Description: Acalisib (GS-9820) is a potent and selective inhibitor of PI3K? with IC50 value of 12.7 nM [1].

Acalisib (GS-9820)
B5831-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 189
Description: Acalisib (GS-9820) is a potent and selective inhibitor of PI3K? with IC50 value of 12.7 nM [1].

Acalisib (GS-9820)
B5831-50	ApexBio	50 mg	EUR 502
Description: Acalisib (GS-9820) is a potent and selective inhibitor of PI3K? with IC50 value of 12.7 nM [1].

Selonsertib (GS-4997)
B7812-100	ApexBio	100 mg	EUR 599
Description: Selonsertib (GS-4997) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor.ASK1, a redox-sensitive mitogen-activated protein kinase kinase kinase, functions as a key signaling node by promoting deleterious effects.

Selonsertib (GS-4997)
B7812-25	ApexBio	25 mg	EUR 290
Description: Selonsertib (GS-4997) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor.ASK1, a redox-sensitive mitogen-activated protein kinase kinase kinase, functions as a key signaling node by promoting deleterious effects.

Selonsertib (GS-4997)
B7812-5	ApexBio	5 mg	EUR 128
Description: Selonsertib (GS-4997) is an apoptosis signal-regulating kinase 1 (ASK1) inhibitor.ASK1, a redox-sensitive mitogen-activated protein kinase kinase kinase, functions as a key signaling node by promoting deleterious effects.

Elvitegravir (GS-9137)
A4070-10	ApexBio	10 mg	EUR 137
Description: Elvitegravir (also known as GS-9137 or JTK-303), a monoketo acid modified from the distinct diketo acid moiety (DKA) motif, is a potent inhibitor of human immunodeficiency virus type I (HIV-1) integrase.

Elvitegravir (GS-9137)
A4070-100	ApexBio	100 mg	EUR 653
Description: Elvitegravir (also known as GS-9137 or JTK-303), a monoketo acid modified from the distinct diketo acid moiety (DKA) motif, is a potent inhibitor of human immunodeficiency virus type I (HIV-1) integrase.

Elvitegravir (GS-9137)
A4070-5.1	ApexBio	10 mM (in 1mL DMSO)	EUR 145
Description: Elvitegravir (also known as GS-9137 or JTK-303), a monoketo acid modified from the distinct diketo acid moiety (DKA) motif, is a potent inhibitor of human immunodeficiency virus type I (HIV-1) integrase.

Elvitegravir (GS-9137)
A4070-50	ApexBio	50 mg	EUR 386
Description: Elvitegravir (also known as GS-9137 or JTK-303), a monoketo acid modified from the distinct diketo acid moiety (DKA) motif, is a potent inhibitor of human immunodeficiency virus type I (HIV-1) integrase.

Cobicistat (GS-9350)
A4313-10	ApexBio	10 mg	EUR 350
Description: Cobicistat is a selective inhibitor of cytochrome P450 (CYP) 3A enzymes with IC50 values ranging from 0.03 to 0.285?M [1].

Cobicistat (GS-9350)
A4313-200	ApexBio	200 mg	EUR 2055
Description: Cobicistat is a selective inhibitor of cytochrome P450 (CYP) 3A enzymes with IC50 values ranging from 0.03 to 0.285?M [1].

Cobicistat (GS-9350)
A4313-5	ApexBio	5 mg	EUR 268
Description: Cobicistat is a selective inhibitor of cytochrome P450 (CYP) 3A enzymes with IC50 values ranging from 0.03 to 0.285?M [1].

50ml Conical Centrifuge Tubes, Green Cap, Sterile, 25unit (cardboard rack)
CT788-GS	Bio Basic	1PK, 25UNIT	EUR 61.35

Recombinant Glutamine synthetase (GS)
4-RPD761Hu01	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Glutamine synthetase expressed in: E.coli

Recombinant Glutamine synthetase (GS)
4-RPD761Mu01	Cloud-Clone	EUR 440.48 EUR 221.00 EUR 1376.80 EUR 525.60 EUR 951.20 EUR 358.00 EUR 3292.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Mouse Glutamine synthetase expressed in: E.coli

Recombinant Glutamine synthetase (GS)
4-RPD761Ra01	Cloud-Clone	EUR 476.32 EUR 230.00 EUR 1511.20 EUR 570.40 EUR 1040.80 EUR 382.00 EUR 3628.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Rat Glutamine synthetase expressed in: E.coli

OVA Conjugated Gelsolin (GS)
4-CPA372Hu21	Cloud-Clone	EUR 386.72 EUR 206.00 EUR 1175.20 EUR 458.40 EUR 816.80 EUR 322.00 EUR 2788.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Human Gelsolin expressed in: Protein conjugation

BSA Conjugated Guanosine (GS)
4-CPO134Ge11	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pan-species Guanosine expressed in: chemical synthesis

OVA Conjugated Guanosine (GS)
4-CPO134Ge21	Cloud-Clone	EUR 413.60 EUR 214.00 EUR 1276.00 EUR 492.00 EUR 884.00 EUR 340.00 EUR 3040.00	100 ug 10ug 1 mg 200 ug 500 ug 50ug 5 mg
Description: Recombinant Pan-species Guanosine expressed in: chemical synthesis

MC Cellufine MAX GS
21-300-51	JNC America	5 x 1 ml	EUR 271

MC Cellufine MAX GS
21-300-55	JNC America	5 x 5 ml	EUR 526

AE-6935GS Visirays-GS
2008011	Atto	1unit	EUR 2384
Description: 490-525nm:peak 505nm

Gelsolin (GS) Antibody Pair
20-abx370115	Abbexa	EUR 1428.00 EUR 926.00	10 × 96 tests 5 × 96 tests

Gelsolin (GS) Antibody Pair
20-abx370757	Abbexa	EUR 1817.00 EUR 1163.00	10 × 96 tests 5 × 96 tests

Gelsolin (GS) Antibody Pair
20-abx370810	Abbexa	EUR 1636.00 EUR 1052.00	10 × 96 tests 5 × 96 tests

Human Gelsolin (GS) Protein
20-abx653524	Abbexa	EUR 578.00 EUR 258.00 EUR 1720.00 EUR 690.00 EUR 425.00	100 ug 10 ug 1 mg 200 ug 50 ug

Monkey Gelsolin (GS) Protein
20-abx653525	Abbexa	EUR 648.00 EUR 272.00 EUR 1998.00 EUR 773.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Glutamine Synthetase (GS) Antibody
20-abx101759	Abbexa	EUR 425.00 EUR 133.00 EUR 1205.00 EUR 578.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Glutamine Synthetase (GS) Antibody
20-abx101760	Abbexa	EUR 439.00 EUR 133.00 EUR 1233.00 EUR 592.00 EUR 328.00	100 ug 10 ug 1 mg 200 ug 50 ug

Glutamine Synthetase (GS) Antibody
20-abx101761	Abbexa	EUR 453.00 EUR 133.00 EUR 1302.00 EUR 620.00 EUR 342.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Gelsolin (GS) Protein
20-abx066765	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Rat Gelsolin (GS) Protein
20-abx066766	Abbexa	EUR 648.00 EUR 272.00 EUR 1943.00 EUR 759.00 EUR 467.00	100 ug 10 ug 1 mg 200 ug 50 ug

Cow Gelsolin (GS) Protein
20-abx066767	Abbexa	EUR 732.00 EUR 286.00 EUR 2263.00 EUR 871.00 EUR 523.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Gelsolin (GS) Protein
20-abx066768	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Gelsolin (GS) Protein
20-abx166832	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Mouse Gelsolin (GS) Protein
20-abx167397	Abbexa	EUR 704.00 EUR 286.00 EUR 2165.00 EUR 829.00 EUR 495.00	100 ug 10 ug 1 mg 200 ug 50 ug

Human Gelsolin (GS) Protein
20-abx168637	Abbexa	EUR 676.00 EUR 286.00 EUR 2082.00 EUR 801.00 EUR 481.00	100 ug 10 ug 1 mg 200 ug 50 ug

Gelsolin (GS) Antibody (Biotin)
20-abx271800	Abbexa	EUR 398.00 EUR 230.00 EUR 1080.00 EUR 537.00 EUR 314.00	100 ug 10 ug 1 mg 200 ug 50 ug

Glutamine synthetase (GS) Antibody
20-abx176646	Abbexa	EUR 1233.00 EUR 592.00	1 mg 200 ug

Glutamine synthetase (GS) Antibody
20-abx172595	Abbexa	EUR 857.00 EUR 439.00	1 mg 200 ug

Fam70A depletion remarkably reduced Akt phosphorylation.Fam70A regulates meiosis and quality of mouse oocytes through both canonical and non-canonical Wnt5a signalling pathways.